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PROTEIN, ATX-2
Descriptors Found:
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DeCS
Descriptor
English
:
Ataxin-2
Descriptor
Spanish
:
Ataxina-2
Descriptor
Portuguese
:
Ataxina-2
Synonyms
English
:
ATXN2 Protein
Ataxin 2
Ataxin 2 Protein
Ataxin-2 Protein
Atx 2 Protein
Atx-2 Protein
Protein, ATXN2
Protein, Ataxin-2
Protein, Atx-2
Protein, SCA2
SCA2 Protein
Spinocerebellar Ataxia Type 2 Protein
Tree Number:
D12.776.157.725.452.125
D12.776.631.069.750
D12.776.660.075.750
D12.776.664.962.452.125
Definition
English
:
A Poly(A) RNA-binding protein that negatively regulates EGFR
ENDOCYTOSIS
. An increased risk for developing
AMYOTROPHIC LATERAL SCLEROSIS
13 is observed in
patients
who have more than 23 CAG repeats in the ATXN2 gene coding sequence. Larger CAG expansions in the ATXN2 gene occur in SPINOCEREBELLAR
ATAXIA
2
patients.
See Related
English
:
Spinocerebellar Ataxias
History Note
English
:
2016; use SCA2 PROTEIN (NM) 1996-2015
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
55986
Unique Identifier:
D000067698
Occurrence in VHL
:
Similar:
DeCS